{"id":52521,"date":"2026-08-08T08:37:38","date_gmt":"2026-08-08T08:37:38","guid":{"rendered":"https:\/\/stagvape.com\/incelemeleri\/vaping-sizofreni-hasari-azaltma-calismasi"},"modified":"2026-08-08T11:03:17","modified_gmt":"2026-08-08T11:03:17","slug":"vaping-sizofreni-hasari-azaltma-calismasi","status":"publish","type":"post","link":"https:\/\/stagvape.com\/tr\/arastirmalari\/vaping-sizofreni-hasari-azaltma-calismasi","title":{"rendered":"Vaping, \u015eizofreni Hastalar\u0131n\u0131n Sigara \u0130\u00e7me Oranlar\u0131n\u0131 D\u00fc\u015f\u00fcr\u00fcyor: \u00c7al\u0131\u015fma Bulgular\u0131"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">21 Temmuz 2026 tarihinde, Catania \u00dcniversitesi\u2019nden Pasquale Caponnetto liderli\u011findeki uluslararas\u0131 bir ara\u015ft\u0131rma ekibi, <a href=\"https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2026.1811946\/full\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2026.1811946\/full\" rel=\"noreferrer noopener nofollow\">Frontiers in Psychiatry<\/a> dergisinde \u015fizofreni spektrum bozuklu\u011fu olan sigara i\u00e7icilerde e-sigaralar\u0131n etkisini de\u011ferlendiren bir derleme yay\u0131mlad\u0131. 2020\u2019den 2026\u2019n\u0131n ba\u015flar\u0131na kadar uzanan klinik verileri analiz eden ara\u015ft\u0131rmac\u0131lar, vaping\u2019in geleneksel sigaray\u0131 b\u0131rakma tedavilerinin olgular\u0131n %90\u2019\u0131ndan fazlas\u0131nda yetersiz kald\u0131\u011f\u0131 bir hasta grubunda etkili bir zarar azaltma stratejisi olarak i\u015flev g\u00f6rd\u00fc\u011f\u00fcn\u00fc tespit etti.<\/p>\n\n<h2 class=\"wp-block-heading\">\u015eizofrenide Sigaran\u0131n Y\u00fcksek Bedeli<\/h2>\n\n<p class=\"wp-block-paragraph\">\u015eizofreni tan\u0131s\u0131 olan bireylerde sigara i\u00e7me oranlar\u0131, genel pop\u00fclasyona k\u0131yasla 2 ila 4 kat daha y\u00fcksektir. Buna ba\u011fl\u0131 olarak, bu grupta t\u00fct\u00fcn kullan\u0131m\u0131 erken \u00f6l\u00fcmlerin ba\u015fl\u0131ca nedeni konumunda; kardiyovask\u00fcler, onkolojik ve solunumsal hastal\u0131klar nedeniyle ya\u015fam s\u00fcresi 15 ila 20 y\u0131l azal\u0131r.<\/p>\n\n<p class=\"wp-block-paragraph\">Nikotin replasman tedavisi, bupropion, vareniklin ve davran\u0131\u015fsal dan\u0131\u015fmanl\u0131k gibi standart b\u0131rakma y\u00f6ntemlerinin bu hastalarda ba\u015far\u0131 oran\u0131 %10\u2019un alt\u0131ndad\u0131r. Tam nikotin yoksunlu\u011funun sa\u011flanmas\u0131n\u0131n zor olmas\u0131 nedeniyle ara\u015ft\u0131rmac\u0131lar, t\u00fct\u00fcn\u00fcn toksik yanma \u00fcr\u00fcnleri olmadan nikotin sa\u011flamak i\u00e7in e-sigaralar\u0131 bir ara\u00e7 olarak de\u011ferlendirmektedir.<\/p>\n\n<h2 class=\"wp-block-heading\">\u00d6ne \u00c7\u0131kan Klinik \u00c7al\u0131\u015fmalar\u0131n Analizi<\/h2>\n\n<p class=\"wp-block-paragraph\">Derleme, 323 kat\u0131l\u0131mc\u0131y\u0131 i\u00e7eren \u00fc\u00e7 prospektif \u00e7al\u0131\u015fmadan elde edilen verileri analiz etti. Bu \u00e7al\u0131\u015fmalarda sigara t\u00fcketiminin azalmas\u0131, zarar\u0131n biyobelirte\u00e7leri ve psikiyatrik stabilite izlendi.<\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th class=\"has-text-align-left\" data-align=\"left\">\u00c7al\u0131\u015fma<\/th><th class=\"has-text-align-left\" data-align=\"left\">\u00dclke ve Kullan\u0131lan Cihaz<\/th><th class=\"has-text-align-left\" data-align=\"left\">Kat\u0131l\u0131mc\u0131 Profili<\/th><th class=\"has-text-align-left\" data-align=\"left\">Ba\u015fl\u0131ca Sonu\u00e7lar<\/th><\/tr><\/thead><tbody><tr><td><strong>Caponnetto ve ark. (2021)<\/strong><\/td><td>\u0130talya; JUUL ( %5 nikotin pod&#8217;u)<\/td><td>\u015eizofreni veya \u015fizoafektif bozuklu\u011fu olan 40 hasta<\/td><td>Sigara t\u00fcketimini %87,5 oran\u0131nda yar\u0131ya indirdiler; 12. haftaya gelindi\u011finde hastalar\u0131n %40\u2019\u0131 tamamen sigaray\u0131 b\u0131rakt\u0131. Psikiyatrik gerileme yok.<\/td><\/tr><tr><td><strong>Pratt ve ark. (2022, 2025)<\/strong><\/td><td>ABD; NJOY tek kullan\u0131ml\u0131k vape<\/td><td>\u015eiddetli ruhsal hastal\u0131\u011f\u0131 (SMI) olan 68 hasta<\/td><td>G\u00fcnl\u00fck sigarada %50 azalma. \u0130drar NNAL (karsinojen belirteci) 4 haftada d\u00fc\u015ft\u00fc; ancak 8. haftaya kadar ikili kullan\u0131m (dual-use) artt\u0131.<\/td><\/tr><tr><td><strong>Kale &amp; Beard (2025)<\/strong><\/td><td>Birle\u015fik Krall\u0131k; Aspire PocketX ( %0,6\u2013%1,8 nikotin)<\/td><td>\u00c7e\u015fitli psikiyatrik durumlar\u0131 olan 43 hasta<\/td><td>Sigara i\u00e7imini yar\u0131 yar\u0131ya azaltanlar\u0131n oran\u0131 %61,9; %9,5\u2019i tamamen sigaray\u0131 b\u0131rakmay\u0131 ba\u015fard\u0131. Psikiyatrik k\u00f6t\u00fcle\u015fme yok.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<h2 class=\"wp-block-heading\">Ba\u015fl\u0131ca Bulgular: G\u00fcvenlik, Karsinojenler ve Klozapin Etkile\u015fimi<\/h2>\n\n<p class=\"wp-block-paragraph\">Derleme, psikiyatrik bak\u0131mda e-sigara kullan\u0131m\u0131na ili\u015fkin birka\u00e7 kritik sonucu \u00f6ne \u00e7\u0131kard\u0131:<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Uygulanabilirlik:<\/strong> T\u00fcm \u00e7al\u0131\u015fmalardaki hastalar vaping cihazlar\u0131n\u0131 isteyerek benimsedi ve y\u00fcksek uyum oranlar\u0131 g\u00f6sterdi; bu da klinik ortamlarda vaping\u2019in kabul edilebilir bir alternatif oldu\u011funu d\u00fc\u015f\u00fcnd\u00fcr\u00fcyor.<\/li>\n\n\n\n<li><strong>Karsinojenlerde Azalma:<\/strong> Ara\u015ft\u0131rmac\u0131lar ekshale edilen karbon monoksiti (CO) ve idrarda NNAL\u2019yi (ba\u015fl\u0131ca t\u00fct\u00fcn karsinojeninin bir metaboliti) \u00f6l\u00e7t\u00fc. Her iki biyobelirte\u00e7 de d\u00fc\u015ft\u00fc; ancak bu azalma yaln\u0131zca hastalar sigaray\u0131 tamamen veyple ikame etti\u011finde kal\u0131c\u0131 hale geldi. \u0130kili kullan\u0131m\u2014vape yap\u0131p sigara i\u00e7meye devam etmek\u2014bu faydalar\u0131 ge\u00e7ersiz k\u0131ld\u0131.<\/li>\n\n\n\n<li><strong>Psikiyatrik Stabilite:<\/strong> Kritik olarak, hi\u00e7bir \u00e7al\u0131\u015fmada psikotik belirtilerde, anksiyetede veya depresyonda art\u0131\u015f kaydedilmedi. Bu, nikotin iletim y\u00f6nteminin de\u011fi\u015ftirilmesinin hastalar\u0131 dengesizle\u015ftirebilece\u011fi y\u00f6n\u00fcndeki psikiyatristlerin temel endi\u015fesini gideriyor.<\/li>\n<\/ul>\n\n<h3 class=\"wp-block-heading\">Kritik Klozapin Etkile\u015fimi<\/h3>\n\n<p class=\"wp-block-paragraph\">Hayati bir klinik bulgu, tedaviye diren\u00e7li \u015fizofrenide re\u00e7ete edilen antipsikotik ila\u00e7 klozapini i\u00e7eriyor. T\u00fct\u00fcn duman\u0131ndaki kimyasallar, klozapini metabolize eden CYP1A2 karaci\u011fer enzimini ind\u00fckler; bu da sigara i\u00e7enlerin ilac\u0131n daha y\u00fcksek dozlar\u0131n\u0131 almas\u0131n\u0131 gerektirir.<\/p>\n\n<p class=\"wp-block-paragraph\">Bir hasta vaping\u2019e ge\u00e7ti\u011finde, t\u00fct\u00fcn duman\u0131n\u0131n olmamas\u0131 bu enzim ind\u00fcksiyonunu durdurur. Bu durum, klozapin d\u00fczeylerinin kanda toksik seviyelere y\u00fckselmesine yol a\u00e7abilir; bu da \u015fiddetli sedasyon, n\u00f6betler veya psikotik belirtilerde k\u00f6t\u00fcle\u015fme gibi sonu\u00e7lara neden olabilir. Yazarlar, klozapin kullanan hastalarda vaping\u2019e yap\u0131lacak her ge\u00e7i\u015fin kan d\u00fczeyi takibi ve doz ayarlamalar\u0131 i\u00e7ermesi gerekti\u011fini vurguluyor.<\/p>\n\n<h2 class=\"wp-block-heading\">\u00c7al\u0131\u015fman\u0131n S\u0131n\u0131rl\u0131l\u0131klar\u0131 ve \u00d6neriler<\/h2>\n\n<p class=\"wp-block-paragraph\">Yazarlar, mevcut ara\u015ft\u0131rmada baz\u0131 s\u0131n\u0131rl\u0131l\u0131klar\u0131n bulundu\u011funu belirtti: genel \u00f6rneklem b\u00fcy\u00fckl\u00fc\u011f\u00fcn\u00fcn k\u00fc\u00e7\u00fck olmas\u0131 (323 kat\u0131l\u0131mc\u0131), tan\u0131sal \u00e7e\u015fitlilik (yaln\u0131zca \u0130talya \u00e7al\u0131\u015fmas\u0131 \u015fizofreniyi m\u00fcnhas\u0131ran ele ald\u0131) ve k\u0131sa izlem s\u00fcreleri (\u00e7o\u011funlukla 12 haftaya kadar). Ayr\u0131ca baz\u0131 yazarlar, farmas\u00f6tik veya vaping end\u00fcstrileriyle finansal ba\u011flant\u0131lar oldu\u011funu bildirdi.<\/p>\n\n<p class=\"wp-block-paragraph\">Klinik a\u00e7\u0131dan derleme, davran\u0131\u015fsal destekle birlikte ikili kullan\u0131m\u0131 \u00f6nlemek ko\u015fuluyla vaping\u2019in pratik bir zarar azaltma se\u00e7ene\u011fi olabilece\u011fini \u00f6ne s\u00fcr\u00fcyor. D\u00fczenleyici yakla\u015f\u0131mlar k\u00fcresel olarak de\u011fi\u015fiyor: Birle\u015fik Krall\u0131k vaping\u2019i b\u0131rakma arac\u0131 olarak desteklerken, Avustralya onu psikiyatrik hastalar i\u00e7in ikinci basamak bir se\u00e7enek olarak kabul ediyor ve ABD, vep\u2019leri onayl\u0131 t\u0131bbi cihazlar olarak de\u011fil t\u00fcketici \u00fcr\u00fcnleri olarak d\u00fczenliyor.<\/p>\n\n<p class=\"wp-block-paragraph\">Erken veriler umut verici olsa da, psikiyatrik klinik uygulamada e-sigaran\u0131n rol\u00fcn\u00fc netle\u015ftirmek i\u00e7in daha b\u00fcy\u00fck ve daha uzun s\u00fcreli denemelere ihtiya\u00e7 var.<\/p>\n\n<ul class=\"wp-block-list\">\n<li>Daha fazlas\u0131n\u0131 okuyun:  <a href=\"https:\/\/stagvape.com\/tr\/arastirmalari\/vaping-saglik-etkileri-guncel-arastirma-2026\" data-type=\"link\" data-id=\"https:\/\/stagvape.com\/study\/vaping-health-effects-current-research-2026\">2026\u2019da Vaping Sa\u011fl\u0131k Etkileri: Ara\u015ft\u0131rma Ne G\u00f6steriyor<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Ara\u015ft\u0131rmac\u0131lar, \u015fizofreni hastalar\u0131 i\u00e7in e-sigaralar\u0131n g\u00fcvenli\u011fini, sigaray\u0131 b\u0131rakma oranlar\u0131n\u0131 ve ila\u00e7 etkile\u015fimlerini analiz ediyor.<\/p>\n","protected":false},"author":1,"featured_media":52522,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[193],"tags":[2762],"class_list":["post-52521","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-arastirmalari","tag-vaping-safety"],"acf":[],"_links":{"self":[{"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/posts\/52521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/comments?post=52521"}],"version-history":[{"count":0,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/posts\/52521\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/media\/52522"}],"wp:attachment":[{"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/media?parent=52521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/categories?post=52521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/tags?post=52521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}