{"id":62939,"date":"2026-09-12T09:12:44","date_gmt":"2026-09-12T09:12:44","guid":{"rendered":"https:\/\/stagvape.com\/incelemeleri\/tobacco-plants-nicotine-biosynthesis-pathway"},"modified":"2026-09-13T09:39:50","modified_gmt":"2026-09-13T09:39:50","slug":"tobacco-plants-nicotine-biosynthesis-pathway","status":"publish","type":"post","link":"https:\/\/stagvape.com\/tr\/arastirmalari\/tobacco-plants-nicotine-biosynthesis-pathway","title":{"rendered":"Bilim \u0130nsanlar\u0131, D\u00fc\u015f\u00fck Nikotinli T\u00fct\u00fcn \u0130\u00e7in T\u00fct\u00fcn Bitkilerinin Nikotini Nas\u0131l \u00dcretti\u011fini \u00d6\u011frendi"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">York \u00dcniversitesi&#8217;ndeki biyokimyagerler, uluslararas\u0131 i\u015f birlik\u00e7ileriyle birlikte, t\u00fct\u00fcn bitkilerinin basit kimyasal yap\u0131 ta\u015flar\u0131ndan nikotin sentezlemek i\u00e7in kulland\u0131\u011f\u0131 enzimatik yolu tamamlad\u0131. Bu ke\u015fif, kimyagerlerin 1828&#8217;de t\u00fct\u00fcn yapraklar\u0131ndan ilk kez nikotin elde etmesinden bu yana varl\u0131\u011f\u0131n\u0131 s\u00fcrd\u00fcren biyolojik bir bilmecenin \u00e7\u00f6z\u00fclmesini sa\u011fl\u0131yor.<\/p>\n\n<p class=\"wp-block-paragraph\">Bulgular, ba\u011f\u0131ml\u0131l\u0131k yap\u0131c\u0131 alkaloidin \u00fcretilmesinden sorumlu genetik ve biyokimyasal mekanizmalar\u0131 a\u00e7\u0131kl\u0131\u011fa kavu\u015fturuyor. Ara\u015ft\u0131rma, tar\u0131msal t\u00fct\u00fcn yeti\u015ftiricili\u011fine y\u00f6nelik etkilerinin \u00f6tesinde, farmas\u00f6tikler, a\u015f\u0131lar ve tan\u0131sal proteinler i\u00e7in \u00fcretim platformu olarak kullan\u0131lan t\u00fct\u00fcn t\u00fcrlerinden nikotinin uzakla\u015ft\u0131r\u0131lmas\u0131na y\u00f6nelik molek\u00fcler ara\u00e7lar sunuyor.<\/p>\n\n<p class=\"wp-block-paragraph\">York \u00dcniversitesi Yeni Tar\u0131msal \u00dcr\u00fcnler Merkezi&#8217;nden Dr. Benjamin Lichman, \u201c200 y\u0131l\u0131 a\u015fk\u0131n s\u00fcredir pe\u015finde oldu\u011fumuz yan\u0131t\u0131 art\u0131k bulmu\u015f olmam\u0131z, bitki bilimi ve biyokimya a\u00e7\u0131s\u0131ndan b\u00fcy\u00fck bir an!\u201d dedi.<\/p>\n\n<h2 class=\"wp-block-heading\">Nikotin Biyosentezi \u0130\u00e7in \u0130ki Y\u00fczy\u0131ll\u0131k Aray\u0131\u015f<\/h2>\n\n<p class=\"wp-block-paragraph\">Nikotin, do\u011fada \u00f6ncelikle bir alkaloid savunma mekanizmas\u0131 olarak i\u015flev g\u00f6r\u00fcr. T\u00fct\u00fcn bitkileri bu bile\u015fi\u011fi k\u00f6klerinde \u00fcretir ve ot\u00e7ul b\u00f6cekleri ile otlayan hayvanlar\u0131 cayd\u0131rmak i\u00e7in yapraklar\u0131na ta\u015f\u0131r. \u0130nsanlar taraf\u0131ndan t\u00fcketildi\u011finde molek\u00fcl, sinir sistemindeki nikotinik asetilkolin resept\u00f6rlerine do\u011frudan ba\u011flanarak uyar\u0131c\u0131 g\u00f6revi g\u00f6r\u00fcr ve fiziksel ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 tetikler.<\/p>\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rmac\u0131lar, onlarca y\u0131ld\u0131r nikotin olu\u015fumu i\u00e7in gerekli temel kimyasal \u00f6nc\u00fclleri biliyordu. Yap\u0131sal analizler, molek\u00fcl\u00fcn tek bir karbon-karbon ba\u011f\u0131yla birle\u015fen iki farkl\u0131 heterosiklik halkadan olu\u015ftu\u011funu do\u011frulad\u0131:<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Bir Piridin Halkas\u0131:<\/strong> Nikotinik asitten (B3 vitamininin bir formu) t\u00fcretilir.<\/li>\n\n\n\n<li><strong>Bir Pirrolidin Halkas\u0131:<\/strong> Amino asit t\u00fcrevi katyon N-metilpirrolinyumdan olu\u015fur.<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\">Kaynak maddeler bilinmesine ra\u011fmen bilim insanlar\u0131, iki halkan\u0131n ba\u011flanmas\u0131ndan sorumlu katalitik mekanizmay\u0131 tan\u0131mlayamad\u0131. Bu molek\u00fcllerin laboratuvar ortamlar\u0131nda do\u011frudan yo\u011funla\u015fmas\u0131n\u0131 g\u00f6zlemleme giri\u015fimleri, nikotinik asit standart biyolojik ko\u015fullarda kimyasal olarak kararl\u0131 kald\u0131\u011f\u0131 i\u00e7in defalarca sonu\u00e7suz kald\u0131. Bir aktivasyon a\u015famas\u0131 olmadan, halkalar\u0131 ba\u011flamak i\u00e7in gereken enerji bariyeri bilinen bitki enzimlerinin a\u015famayaca\u011f\u0131 kadar y\u00fcksek kald\u0131.<\/p>\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"376\" src=\"https:\/\/stagvape.com\/wp-content\/uploads\/2026\/09\/image-2-1024x376.png\" alt=\"T\u00fct\u00fcn Bitkileri Nikotini Nas\u0131l \u00dcretir\" class=\"wp-image-62515\" srcset=\"\/\/stagvape.com\/wp-content\/uploads\/2026\/09\/image-2-1024x376.png 1024w, \/\/stagvape.com\/wp-content\/uploads\/2026\/09\/image-2-300x110.png 300w, \/\/stagvape.com\/wp-content\/uploads\/2026\/09\/image-2-768x282.png 768w, \/\/stagvape.com\/wp-content\/uploads\/2026\/09\/image-2-1536x564.png 1536w, \/\/stagvape.com\/wp-content\/uploads\/2026\/09\/image-2.png 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n<h2 class=\"wp-block-heading\">Mekanizma: Gizli Aktive Edici Glikozilasyon<\/h2>\n\n<p class=\"wp-block-paragraph\">York \u00dcniversitesi ekibi, t\u00fct\u00fcn bitkisinin beklenmedik bir ara \u00fcr\u00fcn olan glikozu kullanarak bu kimyasal engeli a\u015ft\u0131\u011f\u0131n\u0131 ke\u015ffetti. Bitki, bir glikoz \u015feker molek\u00fcl\u00fcn\u00fc ge\u00e7ici olarak nikotinik aside ba\u011flayarak bile\u015fi\u011fi karars\u0131zla\u015ft\u0131r\u0131r ve sonraki enzimatik reaksiyonlar i\u00e7in gereken aktivasyon enerjisini d\u00fc\u015f\u00fcr\u00fcr.<\/p>\n\n<p class=\"wp-block-paragraph\"><strong>Gizli aktive edici glikozilasyon<\/strong> olarak adland\u0131r\u0131lan bu biyolojik strateji, ge\u00e7ici bir molek\u00fcler tutamak g\u00f6revi g\u00f6r\u00fcr. Glikoz \u00f6nc\u00fcl\u00fc aktive ettikten sonra, di\u011fer enzimler halkay\u0131 N-metilpirrolinyuma ba\u011flar. Yap\u0131sal ba\u011f olu\u015fur olu\u015fmaz ba\u015fka bir enzim \u015fekeri kompleksten ay\u0131r\u0131r ve geride tamamlanm\u0131\u015f bir nikotin molek\u00fcl\u00fc b\u0131rak\u0131r.<\/p>\n\n<p class=\"wp-block-paragraph\">Glikoz molek\u00fcl\u00fc nihai \u00fcr\u00fcn enzimatik k\u00fcmeden \u00e7\u0131kmadan \u00f6nce ayr\u0131ld\u0131\u011f\u0131 i\u00e7in, tamamlanm\u0131\u015f alkaloitte hi\u00e7bir kimyasal iz b\u0131rakmad\u0131. Bu ge\u00e7ici yap\u0131, analitik kimyager ku\u015faklar\u0131n\u0131n yolun ara a\u015famalar\u0131n\u0131 neden izole edemedi\u011fini a\u00e7\u0131kl\u0131yor.<\/p>\n\n<p class=\"wp-block-paragraph\">Lichman, \u201cT\u00fct\u00fcn bitkilerinin nikotini nas\u0131l \u00fcretti\u011fine dair bilmece, nikotinin bitkilerden ilk kez elde edildi\u011fi 1820&#8217;lerin sonlar\u0131ndan beri s\u00fcr\u00fcyordu,\u201d dedi. \u201cBu yeni bilgiyle bitkinin do\u011fal olarak \u00fcretti\u011fi nikotini uzakla\u015ft\u0131rabilir veya yeniden de\u011ferlendirebilir, daha iyi biyoteknoloji ara\u00e7lar\u0131 olu\u015fturabiliriz; ayr\u0131ca t\u00fct\u00fcn\u00fcn nikotin olu\u015fturma sistemini yararl\u0131 farmas\u00f6tik bile\u015fikler \u00fcretmek \u00fczere uyarlamak i\u00e7in gelecekte heyecan verici bir potansiyel de bulunuyor.\u201d<\/p>\n\n<h2 class=\"wp-block-heading\">D\u00f6rt Enzimli Kaskad<\/h2>\n\n<p class=\"wp-block-paragraph\">Reaksiyon dizisini do\u011frulamak i\u00e7in ara\u015ft\u0131rma ekibi, t\u00fct\u00fcn dokular\u0131ndan d\u00f6rt farkl\u0131 enzimi izole edip safla\u015ft\u0131rd\u0131 ve canl\u0131 h\u00fccre d\u0131\u015f\u0131nda t\u00fcm metabolik yolu yeniden olu\u015fturdu.<\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th class=\"has-text-align-left\" data-align=\"left\">Enzim<\/th><th class=\"has-text-align-left\" data-align=\"left\">Biyokimyasal \u0130\u015flev<\/th><th class=\"has-text-align-left\" data-align=\"left\">Yoldaki Rol\u00fc<\/th><\/tr><\/thead><tbody><tr><td><strong>NaGT<\/strong><\/td><td>Glikoziltransferaz<\/td><td>Aktif bir ara \u00fcr\u00fcn olu\u015fturmak i\u00e7in nikotinik aside glikoz ba\u011flar.<\/td><\/tr><tr><td><strong>NaGR<\/strong><\/td><td>Red\u00fcktaz<\/td><td>Aktifle\u015fmi\u015f \u00f6nc\u00fcl molek\u00fcl\u00fc indirgemek i\u00e7in hidrojen atomlar\u0131n\u0131 aktar\u0131r.<\/td><\/tr><tr><td><strong>NicGS<\/strong><\/td><td>E\u015fle\u015ftirme Sentaz\u0131<\/td><td>Stereokimyasal kontrol sa\u011flayarak biyolojik olarak aktif (S)-nikotin \u00fcretir.<\/td><\/tr><tr><td><strong>NicGH<\/strong><\/td><td>Glikozidaz \/ Hidrolaz<\/td><td>Ge\u00e7ici glikoz etiketini hidrolize eder ve uzakla\u015ft\u0131rarak saf nikotin elde edilmesini sa\u011flar.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p class=\"wp-block-paragraph\">\u0130lk yazar Benjamin Schwabe, y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckl\u00fc X-\u0131\u015f\u0131n\u0131 kristalografisi kullanarak NaGR ve NicGS&#8217;nin \u00fc\u00e7 boyutlu yap\u0131lar\u0131n\u0131 atomik \u00e7\u00f6z\u00fcn\u00fcrl\u00fckte belirledi. Yap\u0131sal modeller, NicGS&#8217;nin nihai ba\u011f\u0131n uzaysal konfig\u00fcrasyonunu y\u00f6nlendirmek i\u00e7in reaksiyon ara \u00fcr\u00fcnlerini ba\u011flanma cebinde fiziksel olarak konumland\u0131rd\u0131\u011f\u0131n\u0131 ortaya koydu.<\/p>\n\n<p class=\"wp-block-paragraph\">Bu yap\u0131sal kontrol biyolojik a\u00e7\u0131dan belirleyicidir. Biyolojik molek\u00fcller genellikle kiral enantiyomerler, yani ayn\u0131 kimyasal form\u00fcl\u00fcn ayna g\u00f6r\u00fcnt\u00fcs\u00fc olan versiyonlar \u015feklinde bulunur. T\u00fct\u00fcn bitkileri, memeli n\u00f6rolojik resept\u00f6rlerine etkili bi\u00e7imde ba\u011flanan optik izomer olan neredeyse yaln\u0131zca (S)-nikotin \u00fcretir. Ara\u015ft\u0131rmac\u0131lar NicGS olmadan yolu test etti\u011finde sistem, hem sol hem de sa\u011f elli izomerlerden olu\u015fan kontrols\u00fcz rasemik bir kar\u0131\u015f\u0131m \u00fcretti; bu da NicGS&#8217;nin do\u011fal t\u00fct\u00fcn\u00fcn stereokimyasal hassasiyetini belirledi\u011fini kan\u0131tlad\u0131.<\/p>\n\n<h2 class=\"wp-block-heading\">Canl\u0131 Bitki Sistemlerinde Do\u011frulama<\/h2>\n\n<p class=\"wp-block-paragraph\">H\u00fccresiz laboratuvar sentezinin ard\u0131ndan ara\u015ft\u0131rmac\u0131lar, enzimatik yolu canl\u0131 bitki dokusu i\u00e7inde do\u011frulad\u0131. D\u00f6rt enzimi kodlayan genleri, tar\u0131msal ve farmas\u00f6tik ara\u015ft\u0131rmalarda yayg\u0131n olarak kullan\u0131lan yabani bir Avustralya t\u00fct\u00fcn\u00fc akrabas\u0131 olan <em>Nicotiana benthamiana<\/em>&#8216;ya aktard\u0131lar.<\/p>\n\n<p class=\"wp-block-paragraph\">Geneti\u011fi d\u00fczenlenmi\u015f bitkiler, do\u011fal bitki profillerini yans\u0131tan i\u015faretli nikotin molek\u00fclleri \u00fcretti. Ayr\u0131ca ara\u015ft\u0131rmac\u0131lar, kaskad i\u00e7indeki tekil genleri devre d\u0131\u015f\u0131 b\u0131rakarak her ad\u0131m\u0131 do\u011frulad\u0131:<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>NicGH<\/strong>&#8216;nin bask\u0131lanmas\u0131, bitkilerin serbest nikotin \u00fcretmeden kararl\u0131, glikoza ba\u011fl\u0131 nikotin \u00f6nc\u00fcllerini biriktirmesine neden oldu.<\/li>\n\n\n\n<li><strong>NicGS<\/strong>&#8216;nin \u00e7\u0131kar\u0131lmas\u0131, yolun stereospesifikli\u011fini bozarak canl\u0131 h\u00fccresel ortamlardaki d\u00fczenleyici rol\u00fcn\u00fc do\u011frulad\u0131.<\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Molek\u00fcler Tar\u0131m \u0130\u00e7in T\u00fct\u00fcn Platformlar\u0131n\u0131n Geli\u015ftirilmesi<\/h2>\n\n<p class=\"wp-block-paragraph\">Bu d\u00f6rt enzimin tan\u0131mlanmas\u0131, modern biyolojik \u00fcretim i\u00e7in do\u011frudan fayda sa\u011flar. Ticari t\u00fct\u00fcn sigarayla \u00f6zde\u015fle\u015fmi\u015f olsa da, bitki biyologlar\u0131 t\u00fct\u00fcn t\u00fcrlerini molek\u00fcler tar\u0131m i\u00e7in s\u0131k\u00e7a kullan\u0131r; h\u0131zl\u0131 b\u00fcy\u00fcyen bitki dokular\u0131n\u0131 t\u0131bbi proteinler, monoklonal antikorlar ve a\u015f\u0131 antijenleri sentezleyen biyoreakt\u00f6rler olarak de\u011ferlendirir.<\/p>\n\n<p class=\"wp-block-paragraph\"><em>Nicotiana benthamiana<\/em>, haftalar i\u00e7inde y\u00fcksek miktarda biyok\u00fctle vermesi ve ge\u00e7ici ekspresyon vekt\u00f6rlerini kolayca kabul etmesi nedeniyle molek\u00fcler tar\u0131mda tercih edilir. Ancak do\u011fal nikotin \u00fcretimi, kal\u0131c\u0131 bir \u00fcretim engeli olu\u015fturur. Alkaloid, farmas\u00f6tik konsantrasyonlarda insanlar i\u00e7in toksiktir ve hedef proteinlerle birlikte safla\u015f\u0131r; bu nedenle terap\u00f6tik molek\u00fcllerin izole edilmesi i\u00e7in maliyetli, \u00e7ok a\u015famal\u0131 filtrasyon s\u00fcre\u00e7leri gerekir.<\/p>\n\n<p class=\"wp-block-paragraph\">Lichman, \u201cT\u00fct\u00fcn bitkileri biyoteknolojide a\u015f\u0131lar veya di\u011fer farmas\u00f6tik \u00fcr\u00fcnlerin \u00fcretilmesi i\u00e7in platform olarak kullan\u0131labilir, ancak \u00fcr\u00fcnleri kontamine eden ve uzakla\u015ft\u0131r\u0131lmas\u0131 i\u00e7in i\u015flem gerektiren nikotin varl\u0131\u011f\u0131 bu s\u00fcreci zorla\u015ft\u0131r\u0131r,\u201d diye a\u00e7\u0131klad\u0131.<\/p>\n\n<p class=\"wp-block-paragraph\">Tar\u0131msal bilim insanlar\u0131, NaGT veya NicGS&#8217;yi kodlayan genleri devre d\u0131\u015f\u0131 b\u0131rakmak i\u00e7in CRISPR gibi hedefli gen d\u00fczenleme ara\u00e7lar\u0131n\u0131 kullanarak nikotin \u00fcretmeyen t\u00fct\u00fcn hatlar\u0131 geli\u015ftirebilir. Bu bitkiler, alkaloid kontaminasyonunu tamamen ortadan kald\u0131r\u0131rken h\u0131zl\u0131 vejetatif b\u00fcy\u00fcmelerini ve protein sentez kapasitelerini korur; b\u00f6ylece bitki kaynakl\u0131 terap\u00f6tiklerin \u00fcretim maliyetleri d\u00fc\u015fer.<\/p>\n\n<h2 class=\"wp-block-heading\">Yeni Farmas\u00f6tik Alkaloidlerin Tasarlanmas\u0131<\/h2>\n\n<p class=\"wp-block-paragraph\">Ke\u015fif ayr\u0131ca ba\u011f\u0131ml\u0131l\u0131k yapmayan t\u0131bbi bile\u015fiklerin sentezi i\u00e7in enzimatik bir \u00e7er\u00e7eve olu\u015fturuyor. D\u00f6rt enzimli sistemin mod\u00fcler yap\u0131s\u0131, ara\u015ft\u0131rmac\u0131lar\u0131n alternatif \u00f6nc\u00fcl molek\u00fclleri kaskada beslemesine olanak tan\u0131r.<\/p>\n\n<p class=\"wp-block-paragraph\">Kavram kan\u0131tlama denemelerinde ara\u015ft\u0131rma ekibi, \u00f6nc\u00fcl analoglar\u0131n\u0131n ikame edilmesinin enzimlerin nornikotin ve anabazin d\u00e2hil olmak \u00fczere ili\u015fkili alkaloidleri \u00fcretmesini sa\u011flad\u0131\u011f\u0131n\u0131 g\u00f6sterdi. Bitki kaynakl\u0131 bir\u00e7ok alkaloid, merkezi sinir sistemi ila\u00e7lar\u0131, a\u011fr\u0131 tedavileri ve insektisitler i\u00e7in yap\u0131sal omurga g\u00f6revi g\u00f6rd\u00fc\u011f\u00fcnden, bu enzimatik mekanizman\u0131n uyarlanmas\u0131 karma\u015f\u0131k kimyasal bile\u015fiklerin y\u00fcksek s\u0131cakl\u0131kl\u0131 end\u00fcstriyel sentez olmadan \u00fcretilmesi i\u00e7in temiz bir y\u00f6ntem sunar.<\/p>\n\n<p class=\"wp-block-paragraph\">Lichman, \u201cBu ke\u015fif, t\u00fct\u00fcn bitkilerini sigaralarda de\u011fil, ila\u00e7lar ve di\u011fer de\u011ferli \u00fcr\u00fcnler i\u00e7in faydal\u0131 bi\u00e7imde kullanman\u0131n yeni yollar\u0131n\u0131 a\u00e7\u0131yor,\u201d dedi.<\/p>\n\n<ul class=\"wp-block-list\">\n<li>Ara\u015ft\u0131rma bulgular\u0131na <a href=\"https:\/\/www.nature.com\/articles\/s41467-026-72705-0\" target=\"_blank\" rel=\"noopener nofollow\">Nature Communications<\/a> dergisinden \u00e7evrimi\u00e7i olarak eri\u015filebilir.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>York \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131, d\u00fc\u015f\u00fck nikotinli \u00fcr\u00fcnlere olanak sa\u011flamak \u00fczere nikotini olu\u015fturan enzimleri haritaland\u0131rarak 200 y\u0131ll\u0131k bir gizemi \u00e7\u00f6zd\u00fc.<\/p>\n","protected":false},"author":1,"featured_media":62940,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[193],"tags":[2824],"class_list":["post-62939","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-arastirmalari","tag-nicotine"],"acf":[],"_links":{"self":[{"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/posts\/62939","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/comments?post=62939"}],"version-history":[{"count":0,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/posts\/62939\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/media\/62940"}],"wp:attachment":[{"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/media?parent=62939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/categories?post=62939"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stagvape.com\/tr\/wp-json\/wp\/v2\/tags?post=62939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}